Comparison of acquisition and iterative reconstruction parameters in abdominal computed tomography-guided procedures: a phantom study
Original Article

Comparison of acquisition and iterative reconstruction parameters in abdominal computed tomography-guided procedures: a phantom study

Julien Frandon1, Philippe Akessoul1, Aymeric Hamard1, Edinaud Bezandry1, Romaric Loffroy2, Takieddine Addala1, Martin M. Bertrand3, Jean-Paul Beregi1, Joël Greffier1

1Department of Medical Imaging, Nîmes University Hospital, University of Montpellier, Medical Imaging Group Nîmes, EA2992, Nîmes, France; 2Department of Vascular and Interventional Radiology, Image-Guided Therapy Center, ImViA Laboratory-EA 7535, François-Mitterrand University Hospital, Dijon, France; 3Digestive Surgery Department, Nîmes University Hospital, Nîmes, France

Contributions: (I) Conception and design: J Greffier, J Frandon, JP Beregi; (II) Administrative support: JP Beregi, R Loffroy; (III) Provision of study materials or patients: J Greffier, J Frandon, MM Bertrand; (IV) Collection and assembly of data: J Frandon, P Akessoul, J Greffier, A Hamard, T Addala, E Bezandry, MM Bertrand; (V) Data analysis and interpretation: J Frandon, P Akessoul, J Greffier, A Hamard, JP Beregi, MM Bertrand, R Loffroy; (VI) Manuscript drafting: All authors; (VII) Final approval of the manuscript: All authors.

Correspondence to: Julien Frandon, MD, PhD. Département d’Imagerie Médicale, CHU Nîmes, 4 rue du Professeur Robert Debré, 30029 Nîmes, France. Email:

Background: Many computed tomography (CT) navigation systems have been developed to help radiologists improve the accuracy and safety of the procedure. We evaluated the accuracy of one CT computer-assisted guided procedure with different reduction dose protocols.

Methods: A total of 128 punctures were randomly made by two operators on two different anthropomorphic phantoms. The tube voltage was fixed to 100 kVp. Tube currents (mAs) were defined to obtain 4 dose levels: 180 mAs (D1.00), 90 mAs (D0.50), 45 mAs (D0.25) and 15 mAs (D0.10) with respective volume CT dose index (CTDIvol) of 7.02, 3.52, 1.75 and 0.59 mGy. The raw data were reconstructed using level 2 of advanced model-based iterative reconstruction (ADMIRE) (A2) for D1.00, A3 for D0.50, A4 for D0.25 and A5 for D0.10. Two 12-mm targets per phantom were selected. The mean Euclidean distance (EuD) between the tip of the needle and the isocenter of the target was measured for each puncture. The different measures were compared by paired Student’s t-tests.

Results: The mean EuD was 7.0±3.1 mm for the 128 punctures performed. Regardless of which phantom was considered, no significant difference in accuracy occurred between the 4 dose levels, which were 7.1±3.5 mm for D1.00; 7.1±3.1 mm for D0.50; 7.2±3.0 mm for D0.25 and 6.6±2.6 mm for D0.10.

Conclusions: Abdominal CT-guided procedures, using computer-assisted navigation and iterative reconstruction algorithms, allow precise punctures on anthropomorphic phantoms with a dose reduction of −92% compared to a standard protocol.

Keywords: Imaging guided biopsy; computer-assisted; image reconstruction; low-dose computed tomography (low-dose CT); noise reduction

Submitted Mar 24, 2021. Accepted for publication Jun 21, 2021.

doi: 10.21037/qims-21-328


Interventional radiology procedures in oncology that allow physicians to diagnose through percutaneous biopsies or treat various tumors by percutaneous thermoablation have become common minimally invasive practices. Different modalities, including ultrasound, X-ray fluoroscopy, magnetic resonance imaging (MRI) or computed tomography (CT), can be used to help the physician identify the best needle trajectory and guide the needle to the target. Many interventional procedures are now performed under CT guidance because of its availability and its high spatial and contrast resolutions, notably for deep lesions.

Clinical targets are sometimes difficult to reach because they require performing an out-of-plane trajectory to avoid nearby organs. Repetitive helical acquisitions remain mandatory to identify the anatomically safest path because they allow a retrospective analysis of the 3D volume that can identify vascular structures and organs to avoid (1). Considering the recent awareness of the cancer-inducing risks of radiation, dose optimization is currently an important issue (2-10). Regarding helical acquisitions, international practice guidelines for optimization recommend limiting their number and length (1,11-13) and preferring sequential or fluoroscopic acquisitions when possible (3,7,10).

For complex procedures that require repetitive helicoidal acquisitions, which result in higher radiation doses delivered to the patients (13,14), many CT navigation systems have been developed to help radiologists improve the accuracy and safety of the procedure (15,16). Among them is the Imactis® system, a computer-assisted navigation system that provides virtual electromagnetic guidance of the needle in a 3D space. Imactis® has been shown to improve accuracy for both simple and complex trajectories and to reduce the number of helical acquisitions required (17,18).

However, dose optimization may not depend only on clinical practice optimization. Recent CT scans with new tools, such as iterative reconstruction algorithms, allow significant dose reductions for helical acquisitions as well (19,20) while maintaining an image quality sufficient for diagnosis or lesion detection (21-23). Optimization in CT-guidance protocols for interventional radiology procedures consists of striking an appropriate balance between the radiation dose delivered to the patient and the image quality required to guide the needle. We conjecture that the image quality obtainable under very low dose protocol, which is sufficient for certain diagnosis and detection of lesions, may also be sufficient to guide difficult CT interventions.

The primary objective in the present study was to evaluate the feasibility and accuracy of computer-assisted CT-guided puncture at different reduced doses on two anthropomorphic phantoms. The secondary objectives were to evaluate the impacts of operator experience (junior or senior operator) using two different phantoms with different relative target densities (hyper- or hypodense targets), the obliquity of the trajectory (simple or double obliquity) and the depth of the target (superficial or deep target) on the accuracy of CT-guided procedures at reduced doses.



Two anthropomorphic phantoms (CIRS, Norfolk, VA, USA) were used to perform abdominal punctures. The image-guided abdominal biopsy phantom model 071B (phantom 1) corresponds to a simplified abdominal phantom with 12 hyperdense targets (80 UH for a background of 35 UH; diameter from 5 to 12 mm) that could mimic retroperitoneal nodes, for example. The triple-modality 3D abdominal phantom model 057A (phantom 2) corresponds to a small adult abdomen with 8 hypodense targets (30 UH for a background of 75 UH; diameter from 5 to 12 mm) that can, for example, mimic metastatic liver lesions (Figure 1).

Figure 1 The two phantoms used in the study. Phantom 1 is depicted on the left (A) with hyperdense targets (white arrowhead) and the Imactis® magnetic transmitter (white asterisk). Phantom 2 is depicted on the right (B) with hypodense targets (black arrowhead).

CT protocol

Acquisitions were performed on a Somatom Definition AS + CT unit (Siemens Healthineers, Erlangen, Germany) using a tube voltage of 100 kVp, a beam collimation of 128 mm × 0.6 mm, a pitch factor of 0.8 and a rotation time of 0.5 s. Tube currents were defined to obtain four dose levels: 180 mAs (D1.00, standard dose), 90 mAs (D0.50, a twofold dose reduction), 45 mAs (D0.25, VLD, a fourfold dose reduction) and 15 mAs (D0.10, a tenfold dose reduction). The respective CTDIvol values were 7.02, 3.52, 1.75 and 0.59 mGy. The tube-current modulation system was disabled for each acquisition.

The raw data were reconstructed with the advanced model-based iterative reconstruction algorithm (ADMIRE) using the standard soft tissue reconstruction kernel (I30f). According to the Imactis® navigation system recommendations, the images were reconstructed at a slice thickness of 3.0 mm (at a 2.0 mm increment). A 350-mm field of view was used to be close to the morphologies of both phantoms. A preliminary evaluation visually studied the influence of the ADMIRE levels on the different dose levels (Supplementary Appendix: section 1; Tables S1,S2, and Figure S1). ADMIRE Level 2 (A2) was used for D1.00, A3 for D0.50, A4 for D0.25 and A5 for D0.10 (Figure 2).

Figure 2 Phantoms with the four dose levels: D1.00 with ADMIRE 2, D0.50 with ADMIRE 3, D0.25 with ADMIRE 4 and D0.10 with ADMIRE 5. Left: phantom 1; right: phantom 2. D1.00: 180 mAs, CTDIvol =7.02 mGy; D0.50: 90 mAs, CTDIvol =3.52 mGy; D0.25: 45 mAs, CTDIvol =1.75 mGy; D0.10: 15 mAs, CTDIvol =0.59 mGy. ADMIRE, advanced model-based iterative reconstruction; CTDIvol, volume computed tomography dose index.

Puncture procedure

Two 12-mm diameter targets, one superficial (6 cm below the skin) and one deep (at 12 cm), were defined for each phantom. For each target, four puncture entry points were defined, two in the same plane (simple obliquity) and two out of plane (double obliquity with the angles in the x- and z-axes both >10°). Punctures were performed with a graduated needle with a 17-Ga coaxial introducer (Argon Medical device, Dallas, USA) using the Imactis® navigation system (Supplementary Appendix: section 2; Figure S2).

The punctures were performed by two radiologists: one was a senior radiologist (J Frandon) and the other was a junior radiologist (P Akessoul). The senior radiologist (5 years of experience) had routinely used the Imactis® navigation system, but the junior radiologist (6 months of experience) had never used it. He received 1-hour basic theoretical training by the senior prior to the start of the study.

A total of 128 different scenarios were studied with different configurations: operator (n=2), phantom (n=2), target (n=2), entry point (n=4) and dose level (n=4). The procedures were performed consecutively on each phantom after randomizing the order of the different scenarios. The procedures on the two phantoms were conducted during two different sessions. The operators were blinded to the dose levels.

Two acquisitions were performed for each procedure. After the prepuncture acquisition, the images were transferred to Imactis® to plan the needle trajectory and evaluate its length. The puncture was then performed in one shot. The length of the needle was computed in the navigation system prior to the punction so that the needle length inserted was virtually followed without performing intermediate CT acquisition. A postpuncture control acquisition was performed to assess accuracy (Figure 3).

Figure 3 Example of simple obliquity (SO) and double obliquity (DO) punctures on phantom 2 with pre- and postprocedural CT at the four different dose levels. Windowing was adopted to show the needle tip. The artifacts differ between SO and DO punctures. D1.00: 180 mAs, CTDIvol =7.02 mGy; D0.50: 90 mAs, CTDIvol =3.52 mGy; D0.25: 45 mAs, CTDIvol =1.75 mGy; D0.10: 15 mAs, CTDIvol =0.59 mGy. CTDIvol, volume computed tomography dose index; DO, double obliquity; SO, simple obliquity.


Accuracy evaluation

The accuracy of each procedure was evaluated by measuring the 3D Euclidean distance (EuD), i.e., the 3D distance between the needle tip and the target isocenter (24). The distance was measured using Syngo.Via on a VB30 workstation (Siemens Healthineers, Erlangen, Germany) by one independent reader (E Bezandry) who was blinded to the procedure characteristics (operators, doses). If the target was not visible in the postprocedure acquisition because of artifacts, the preprocedure image was used with a needle projection and image fusion. The procedure duration was recorded only on phantom 2.

Objective analysis of image quality

The objective image quality was analyzed using Syngo.Via on the VB30 workstation. For each acquisition, circular regions of interest (ROIs) were placed inside (0.5 cm2 diameter) and outside the target (background, 1 cm2). The mean attenuation (average number of pixels; HU value) and the image noise (standard deviation of pixels; σ) were computed for each ROI.

The contrast-to-noise ratio (CNR) between the target and the background was calculated as follows:


Subjective image quality and confidence level analysis

Immediately after each puncture, both radiologists assessed the subjective image quality on Imactis® using the following scale: 1 = target difficult to detect on the two orthogonal plans reconstructed by Imactis®; 2 = target difficult to detect on one of the two plans; 3 = target detectable on the two plans, with intermediate noise; 4 = target perfectly detectable on 1 of the 2 plans; 5 = target perfectly detectable on both plans. A score ≥3 was considered sufficient to provide good guidance. Radiologists also assessed their confidence levels after the procedure as follows: 1 = target probably not reached; 2 = target possibly reached; 3 = target probably reached; 4 = target most likely reached; 5 = target reached with certainty. A confidence level ≥4 reflected good confidence in the procedure.

Statistical analysis

Data processing and analysis were conducted with R (v3.20) and RStudio (v0.98.113). The variables are presented as means and standard deviations. They were compared using paired Student’s t-tests for parametric variables, Mann-Whitney Wilcoxon tests for nonparametric variables and ANOVA for multiple parametric variables. P values below 0.05 were considered statistically significant. For subjective data, the interoperator agreement for each protocol was computed by Cohen’s kappa (poor, κ =0.00–0.20; fair κ =0.21–0.40; moderate κ =0.41–0.60, good, κ =0.61–0.80; excellent, κ =0.81–1.00).


Feasibility of the protocol

The Imactis® navigation system functioned properly at all the different dose levels and provided accurate virtual guidance in the 3D volume. The targets were visible in all the preprocedural acquisitions.

However, the target was not visible in 8 of the postpuncture acquisitions (8/128, 6.3%) because of needle artifacts; of these, 5 occurred using D0.10 (5/32; 15.6%) and 3 using D0.25 (3/32; 9.4%) (Figure 3).

Accuracy evaluation of punctures with dose reduction

The mean EuD was 7.0±3.1 mm for the 128 punctures performed. The puncture accuracy was not altered by the dose reduction: the mean EuD values were 7.1±3.5 mm for D1.00, 7.1±3.1 mm for D0.50, 7.2±3.0 mm for D0.25 and 6.6±2.6 mm for D0.10 (Table 1 and Figure 4).

Table 1

Euclidean distance (mm) between the isocenter of the 12-mm target and the tip of the needle as a function of operator experience, phantom used, depth and obliquity of the punctured target for each dose level

Configuration D1.00 D0.50 D0.25 D0.10 All
Simple obliquity 7.4±3.7 7.1±3.7 6.5±2.3 6.6±2.1 6.9±3.0
Double obliquity 6.8±3.3 7.2±2.5 7.9±3.5 6.5±3.2 7.1±3.1
Superficial target 6.0±2.1 7.8±3.6 7.9±2.7 7.4±2.7 7.3±2.9
Deep target 8.2±4.2 6.4±2.5 6.5±3.2 5.7±2.3 6.7±3.2
Phantom 1 7.5±4.1 7.7±3.7 8.3±3.2 6.8±2.7 7.6±3.4
Phantom 2 6.6±2.8 6.5±2.4 6.1±2.4 6.3±2.7 6.4±2.5
Senior 6.8±3.1 7.6±2.7 7.2±2.6 6.4±2.0 7.0±2.6
Junior 7.4±3.9 6.7±3.5 7.2±3.4 6.7±3.2 7.0±3.5
All 7.1±3.5 7.1±3.1 7.2±3.0 6.6±2.6 7.0±3.1

Values are expressed as mean ± standard deviation. D1.00: 180 mAs, CTDIvol =7.02 mGy; D0.50: 90 mAs, CTDIvol =3.52 mGy; D0.25: 45 mAs, CTDIvol =1.75 mGy; D0.10: 15 mAs, CTDIvol =0.59 mGy. CTDIvol, volume computed tomography dose index.

Figure 4 Boxplot of the mean Euclidean distance (mm) between the isocenter of the 12 mm target and the tip of the needle according to the protocol used. D1.00: 180 mAs, CTDIvol =7.02 mGy; D0.50: 90 mAs, CTDIvol =3.52 mGy; D0.25: 45 mAs, CTDIvol =1.75 mGy; D0.10: 15 mAs, CTDIvol =0.59 mGy. P value lower than 0.05 was considered significant. CTDIvol, volume computed tomography dose index.

Punctures accuracy under different scenarios

Operator experience, obliquity and depth had no significant effect on puncture accuracy, regardless of the dose level (Figure 5). The punctures were significantly more accurate when performed on phantom 2 than on phantom 1 (6.4±2.5 vs. 7.6±3.4 mm, P=0.02). However, no differences occurred between the EuDs reported for the first 10 and last 10 procedures on each phantom.

Figure 5 Boxplot of the mean Euclidean distance (mm) between the isocenter of the 12 mm target and the tip of the needle as a function of obliquity, target depth, phantom and operator experience. P value lower than 0.05 was considered significant.

The mean procedure duration was not significantly different between the different dose levels, although there was a tendency toward longer times under reduced doses. Mean procedure durations were 39±12 s for D1.00 dose, 36±14 s for D0.50, 43±22 s for D0.25 and 59±28 s for D0.10 (P=0.052). The junior operator spent significantly more time on each puncture (mean procedure duration of 51±25 s) than did the senior operator (mean procedure duration of 38±14 s, P=0.02) (Figure 6).

Figure 6 Mean procedure time (s) for both operators according to the protocol used. D1.00: 180 mAs, CTDIvol =7.02 mGy; D0.50: 90 mAs, CTDIvol =3.52 mGy; D0.25: 45 mAs, CTDIvol =1.75 mGy; D0.10: 15 mAs, CTDIvol =0.59 mGy. P value lower than 0.05 was considered significant. CTDIvol, volume computed tomography dose index.

Objective analysis of image quality

The mean attenuation of the target and background were not significantly different for all dose levels on phantom 2, but it was significant for the targets on the phantom (P<0.001). Noise increased with dose reduction and was significantly higher (P<0.001) for D0.10 than for D1.00 for both targets and background. The CNR decreased with dose reduction and was significantly lower for D0.10 than for D1.00 (P<0.001) (from −43% to −36%) (Table 2).

Table 2

Quantitative analysis and comparison between the four dose levels

Objective image quality Parameters D1.00 D0.50 D0.25 D0.10 Difference [D0.10 vs. D1.00 (%)] P value (D0.10 vs. D1.00)
Mean attenuation (HU) Targets, phantom 1 81.5±6 80.5±3.5 77.6±1.9 69.1±4.5 −15 <0.001
Background, phantom 1 34.9±1.0 34.9±1.2 35.1±1.4 33.3±3.1 −5 0.07
Targets, phantom 2 31.4±3.2 31.5±3.2 31.2±5.2 30.9±3.2 −2 0.62
Background, phantom 2 74.6±2.9 74.1±2.9 74.9±1.8 74.3±1.7 0 0.60
Noise (HU) Targets, phantom 1 9.5±2.1 9.6±2.4 10.5±1.5 14.1±2.6 49 <0.001
Background, phantom 1 9.5±0.7 9.6±1.4 11.8±1.4 15.0±1.4 58 <0.001
Targets, phantom 2 7.1±1.0 9.9±1.0 10.8±1.4 11.1±2.2 58 <0.001
Background, phantom 2 8.1±1.0 10.5±0.8 11.0±0.9 13.8±1.0 69 <0.001
CNR Targets, phantom 1 4.9±0.7 4.9±0.9 3.8±0.3 2.5±0.5 −49 <0.001
Targets, phantom 2 5.7±1.0 4.2±0.5 4.0±0.5 3.5±0.5 −39 <0.001

D1.00: 180 mAs, CTDIvol =7.02 mGy; D0.50: 90 mAs, CTDIvol =3.52 mGy; D0.25: 45 mAs, CTDIvol =1.75 mGy; D0.10: 15 mAs, CTDIvol =0.59 mGy. CTDIvol, volume computed tomography dose index; CNR, contrast-to-noise ratio; HU, Hounsfield unit.

Subjective image quality and confidence level analysis

Both the image quality and confidence level decreased with dose reduction for both operators. Overall, the junior operator tended to rate both the image quality and confidence level at lower values than did the senior operator. For D1.00, the image quality was scored as ≥3 for 100% of procedures for both radiologists; however, for D0.10, image quality reached ≥3 in only 44% of the procedures by the senior and 19% by the junior.

For D1.00, the confidence level was scored as ≥4 for 100% of procedures by the senior and 56% by the junior; however, for D0.10 it reached only for 13% and 0% of procedures for the senior and the junior, respectively (Table 3).

Table 3

Subjective evaluation of image quality and confidence level

Subjective image quality Parameters D1.00 D0.50 D0.25 D0.10
Senior Junior Senior Junior Senior Junior Senior Junior
Image quality Target perfectly detectable in both parts of the screen 13 11 7 8 5 0 0 1
Target perfectly detectable on one of the two parts of the screen 2 4 7 5 4 6 1 0
Target detectable with intermediate noise level or artifact 1 1 2 2 7 6 6 2
Target difficult to detect on 1 of the 2 parts of the screen 0 0 0 1 0 4 5 7
Target difficult to detect on both parts of the screen 0 0 0 0 0 0 4 6
Interobserver agreement (95% confidence interval) (κ) 0.830 (0.476–1.183) 0.801 (0.455–1.147) 0.495 (0.255–0.735) 0.568 (0.288–0.847)
Confidence level The target is reached with certainty 4 3 1 5 3 2 1 0
Target is most likely reached 8 6 11 6 5 4 1 0
The target is probably reached 4 6 4 4 7 7 12 9
Target may be reached 0 0 0 1 1 3 0 3
The target is probably not reached 0 1 0 0 0 0 2 4
Interobserver agreement (95% confidence interval) (κ) 0.721 (0.401–1.041) 0.527 (0.246–0.807) 0.344 (0.149–0.538) 0.429 (0.155–0.702)

D1.00: 180 mAs, CTDIvol =7.02 mGy; D0.50: 90 mAs, CTDIvol =3.52 mGy; D0.25: 45 mAs, CTDIvol =1.75 mGy; D0.10: 15 mAs, CTDIvol =0.59 mGy. CTDIvol, volume computed tomography dose index.

The interobserver agreement for all dose levels was good for both image quality evaluation (κ =0.795, 95% CI: 0.667–0.924) and for confidence level (κ =0.778, 95% CI: 0.635–0.922); however, it decreased with dose reduction. For D1.00, the interobserver agreements were excellent for image quality and good for confidence level, but they were moderate for these two criteria for D0.10 (Table 3).


Computer-assisted CT-guided puncture was both feasible and accurate with no significant differences at different dose reduction protocols from D1.00 to D0.10, in which the dose was reduced by 91.6%. The experiment showed no influence from operator experience, obliquity path or target depth on the accuracy. However, the operators felt significantly less confident for D0.10.

Many CT navigation systems exist that provide precise puncture locations to help guide radiologists (15). Imactis® is one of the easiest and most ergonomic to use; unlike many other electromagnetic guidance systems it provides real-time needle tracking (25-27). In contrast, laser (28) and optical guidance (25) systems are limited because they require a direct line between the markers and the detection system. However, one drawback of Imactis® is that the use of helicoidal acquisition is mandatory. Indeed, optimization recommendations involve limiting the length and number of helicoidal acquisitions and preferring sequential or fluoroscopic acquisition when possible (1,11-13). The greatest exposures occur during plan acquisition and final control, where helical mode contributed 82% of the total dose length product (DLP) in a recent multicentric study (13). Some studies have proposed adapting mAs and kVp to patient size and diameter to help reduce the dose (12,29). Lucey et al. evaluated the feasibility of a low-dose protocol for CT control during the procedure with current reductions of up to 30 mAs but with no modifications to kVp (120–140) (30). The purpose of this study was to optimize our interventional protocols in the same way to investigate how far dose reduction can go without altering the puncture accuracy. The tube voltage was not modified; it was fixed to 100 kVp to be coherent with abdominal puncture. However, the tube current was reduced from 180 to 15 mAs to reduce the dose level (the CTDIvol ranged from 7.02 to 0.59 mGy). Different levels of iterative reconstruction were defined to maintain sufficient image quality to aid in punctures. Alagic et al. also demonstrated that iterative reconstruction could help reduce the dose level for musculoskeletal biopsies (8).

The present study found that accuracy was not dependent on operator experience or trajectory difficulty, as was demonstrated in a randomized trial studying Imactis® precision (17). This showed for the first time that the dose, even a dose reduction of −92% compared to standard protocol, does not alter the accuracy or risk of punctures. Accuracy was lower than in a study by Durand et al. (7.0 vs. 4.1 mm) (17), which may be due to the different methods of measurement used here [EuD (31)] and the one-shot protocol with 100% virtual guidance and no intermediate control to adapt the needle position. Indeed, Imactis® is a passive guidance system and potential movement of the operator during the insertion cannot be corrected without intermediate control. The punctures were significantly less accurate when using phantom 1 than when using phantom 2 (7.6±3.4 vs. 6.4±2.5 mm, P=0.02), which could be related to the composition of phantom 1 (dense targets in a monobloc of soft Zerdine®) and reciprocal movements between the needle and target. The second phantom was closer to reality with a homogenous dense structure and a filling inside representing the target.

Although the accuracy was not altered by dose reduction, subjective image quality and operator confidence levels were not as good with D0.10, with ratings of 56% for sufficient quality and only 13% for confidence. The evaluations were worse for the junior, who rated sufficient image quality at only 19% and rated the confidence at 0% with D0.10. This difference could be reduced if the time spent performing the puncture were longer with D0.10. However, the accuracy was the same, showing the safety of the procedure with careful puncture. This result was also found in another study evaluating subjective image quality with D0.10 acquisition (21,22). This result emphasizes the necessity for changing the operator’s mind, switching the operator's expectation from a “good” image to a “sufficient” image. The radiologist would need to learn to be comfortable with a sufficient image quality that allows precise puncture. It also emphasizes the necessity for developing specific conditions in which trainees can learn to work with D0.10 images.

This study shows the feasibility of ultra-low-dose puncture thanks to the use of an iterative reconstruction algorithm and it can serve as guidance for a further human study. The D0.10 protocol can be a good benchmark to begin the procedure. The advantage of Imactis® is that it is an external navigation system that can be stopped or switched to a higher dose level at any moment. Indeed, Lucey et al., in their low-dose protocol, which did not use iterative reconstruction, found that the target was not visualized in 13 of 201 patients, who required novel acquisition under a higher dose (30). All the targets were visible on the prepuncture acquisitions in our study, but we can imagine a similar protocol in clinical practice with a switch to D0.25 or D0.50 if D0.10 did not allow the target to be seen.

The study has some limitations, mainly due to its design and the use of phantoms that cannot reproduce real situations (e.g., respiratory movement, height and weight differences, need to avoid perforation of small blood vessels and bile ducts). The stereotypic punctures used here could lead to a learning curve despite the randomization of the scenarios. Moreover, some permanent tracking might be evident if debris and air bubbles were entrained in the gel during the biopsy procedure. Although we found no differences in accuracy between the first and last punctures, we cannot exclude the possibility of a learning bias. Stereotypic targets cannot replace clinical practice, in which lesions could be isodense and thus less visible. However, it has been shown that D0.10 images can be used to detect hypodense lesions with precision in abdominal imaging (21). The punctures were performed on a single CT scan, so the protocol defined could only be transferrable to CT scans using a similar iterative reconstruction algorithm. The targets could not be seen due to needle artifacts in 15.6% of the D0.10 postprocedural acquisitions, which could be challenging to iterative control in clinical use. Last, a baseline navigation error is associated with this specific needle guidance system. The results found in this study may not apply to other navigation systems.


The computer-assisted CT-guided procedures were precise regardless of the dose, trajectory obliquity, target depth, or operator experience. Using 2 anthropomorphic phantoms, this study showed the feasibility of performing punctures even under dramatic dose reduction. The study investigated using different levels of iterative reconstruction, from a standard dose to −91.6% dose reduction (D0.10). Puncture accuracy was unaffected and was the same under all dose reduction protocols, with either a junior or senior operator, mono- or double obliquity paths, and superficial or deep targets. However, with −91.6% dose reduction (D0.10) operator confidence in the procedure was reduced, and clinical evaluations were performed.


The authors thank Dr. Hélène de Forges for her help and her participation in the study. They also thank the Clinical Research Department of the Nîmes University Hospital and the BESPIM unit for their methodologic, regulatory and administrative support throughout the study.

Funding: The study was funded by an internal Nîmes University Hospital call for projects, NIMAO, funding number NIMAO/2018-02/JF-01.


Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at Dr. RL serves as an unpaid deputy editor of Quantitative Imaging in Medicine and Surgery. The other authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted only on phantoms, no patient was included. Ethical approval and written informed consent are not applicable for this study.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:


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Cite this article as: Frandon J, Akessoul P, Hamard A, Bezandry E, Loffroy R, Addala T, Bertrand MM, Beregi JP, Greffier J. Comparison of acquisition and iterative reconstruction parameters in abdominal computed tomography-guided procedures: a phantom study. Quant Imaging Med Surg 2022;12(1):281-291. doi: 10.21037/qims-21-328