TY - JOUR AU - Shu, Xiao AU - Beckmann, Lisa AU - Wang, Yuanbo AU - Rubinoff, Ian AU - Lucy, Katie AU - Ishikawa, Hiroshi AU - Wollstein, Gadi AU - Fawzi, Amani A. AU - Schuman, Joel S. AU - Kuranov, Roman V. AU - Zhang, Hao F. PY - 2019 TI - Designing visible-light optical coherence tomography towards clinics JF - Quantitative Imaging in Medicine and Surgery; Vol 9, No 5 (May 31, 2019): Quantitative Imaging in Medicine and Surgery (Advanced Optical Imaging in Biomedicine Special Issue) Y2 - 2019 KW - N2 - Background: The capabilities of visible-light optical coherence tomography (vis-OCT) in noninvasive anatomical and functional retinal imaging have been demonstrated by multiple groups in both rodents and healthy human subjects. Translating laboratory prototypes to an integrated clinical-environment-friendly system is required to explore the full potential of vis-OCT in disease management. Methods: We developed and optimized a portable vis-OCT system for human retinal imaging in clinical settings. We acquired raster- and circular-scan images from both healthy and diseased human eyes. Results: The new vis-OCT provided high-quality retinal images of both subjects without any known eye diseases and patients with various retinal diseases, including retinal occlusive disease and diabetic retinopathy (DR) over a broad range of ages. Conclusions: A newly designed vis-OCT system is sufficiently optimized to be suited for routine patients’ examinations in clinics. Vis-OCT has the potential to add new anatomical and functional imaging capabilities to ophthalmic clinical care. UR - https://qims.amegroups.org/article/view/25886