Left ventricular ‘rigid body rotation’ in a patient with acromegaly (from the MAGYAR-Path Study)

Cardiovascular complications are known features in acromegaly due to growth hormone (GH) and insulin-like growth factor 1 (IGF-1) excess (1,2). In healthy subjects, left ventricular (LV) apex and base rotate in opposite directions resulting in a towel-wringing-like motion called as LV twist, which could be easily and non-invasively quantified by three-dimensional (3D) speckle-tracking echocardiography (3DSTE) (3). However, little is known about LV myocardial rotational mechanics in acromegaly.