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Carbon coated superparamagnetic iron oxide nanoparticles for sentinel lymph nodes mapping

  
@article{QIMS81,
	author = {Yi-Xiang J Wang and Da-Wei Wang and Xiao-Ming Zhu and Feng Zhao and Ken CF Leung},
	title = {Carbon coated superparamagnetic iron oxide nanoparticles for sentinel lymph nodes mapping},
	journal = {Quantitative Imaging in Medicine and Surgery},
	volume = {2},
	number = {1},
	year = {2011},
	keywords = {},
	abstract = {Intra-operative lymphatic mapping and sentinel lymph-adenectomy (LM/SL) maps the lymphatic path from the primary tumor to the regional nodes and permits selective excision of the first sentinel lymph nodes. It is a well established technique to detect occult regional node metastases for melanoma patients and breast cancer patients. In continuing attempts to improve accuracy, most surgeons now combine a dye (such as carbon particles) and radiopharmaceuticals when performing LM/SL. We developed a proto-type of carbon coated superparamagnetic iron oxide nanoparticles (SPIO@C) for sentinel lymph nodes mapping. Compared with combining carbon particles and radiopharmaceuticals for performing LM/SL, there are a number of advantages with our approach: I. SPIO is an MRI contrast agent, thus pre-operative MRI may be used for LM/SL instead of gamma camera. There is no radiation associated with MRI, and MRI offers good tissue contrast and detailed cross-sectional images. II. There will be only needed one injection of SPIO@C nanoparticles, instead of administrating two successive injections of radiopharmaceuticals and carbon particles. III. During the operation, an intraoperative MRI scanner can be used, or more conveniently by a simple magnetometer.},
	url = {http://qims.amegroups.com/article/view/81}
}