%0 Journal Article %T Hepatic steatosis assessment using ultrasound homodyned-K parametric imaging: the effects of estimators %A Zhou, Zhuhuang %A Zhang, Qiyu %A Wu, Weiwei %A Lin, Ying-Hsiu %A Tai, Dar-In %A Tseng, Jeng-Hwei %A Lin, Yi-Ru %A Wu, Shuicai %A Tsui, Po-Hsiang %J Quantitative Imaging in Medicine and Surgery %D 2019 %B 2019 %9 %! Hepatic steatosis assessment using ultrasound homodyned-K parametric imaging: the effects of estimators %K %X Background: The homodyned-K (HK) distribution is an important statistical model for describing ultrasound backscatter envelope statistics. HK parametric imaging has shown potential for characterizing hepatic steatosis. However, the feasibility of HK parametric imaging in assessing human hepatic steatosis in vivo remains unclear. Methods: In this paper, ultrasound HK μ parametric imaging was proposed for assessing human hepatic steatosis in vivo . Two recent estimators for the HK model, RSK (the level-curve method that uses the signal-to-noise ratio (SNR), skewness, and kurtosis based on the fractional moments of the envelope) and XU (the estimation method based on the first moment of the intensity and two log-moments, namely X- and U -statistics), were investigated. Liver donors (n=72) and patients (n=204) were recruited to evaluate hepatic fat fractions (HFFs) using magnetic resonance spectroscopy and to evaluate the stages of fatty liver disease (normal, mild, moderate, and severe) using liver biopsy with histopathology. Livers were scanned using a 3-MHz ultrasound to construct μ RSK and μ XU images to correlate with HFF analyses and fatty liver stages. The μ RSK and μ XU parametric images were constructed using the sliding window technique with the window side length (WSL) =1–9 pulse lengths (PLs). The diagnostic values of the μ RSK and μ XU parametric imaging methods were evaluated using receiver operating characteristic (ROC) curves. Results: For the 72 participants in Group A, the μ RSK parametric imaging with WSL =2–9 PLs exhibited similar correlation with log 10 (HFF), and the μ RSK parametric imaging with WSL = 3 PLs had the highest correlation with log 10 (HFF) (r=0.592); the μ XU parametric imaging with WSL =1–9 PLs exhibited similar correlation with log 10 (HFF), and the μ XU parametric imaging with WSL =1 PL had the highest correlation with log 10 (HFF) (r=0.628). For the 204 patients in Group B, the areas under the ROC (AUROCs) obtained using μ RSK for fatty stages ≥ mild (AUROC 1 ), ≥ moderate (AUROC 2 ), and ≥ severe (AUROC 3 ) were (AUROC 1 , AUROC 2 , AUROC 3 ) = (0.56, 0.57, 0.53), (0.68, 0.72, 0.75), (0.73, 0.78, 0.80), (0.74, 0.77, 0.79), (0.74, 0.78, 0.79), (0.75, 0.80, 0.82), (0.74, 0.77, 0.83), (0.74, 0.78, 0.84) and (0.73, 0.76, 0.83) for WSL =1, 2, 3, 4, 5, 6, 7, 8 and 9 PLs, respectively. The AUROCs obtained using μ XU for fatty stages ≥ mild, ≥ moderate, and ≥ severe were (AUROC 1 , AUROC 2 , AUROC 3 ) = (0.75, 0.83, 0.81), (0.74, 0.80, 0.80), (0.76, 0.82, 0.82), (0.74, 0.80, 0.84), (0.76, 0.80, 0.83), (0.75, 0.80, 0.84), (0.75, 0.79, 0.85), (0.75, 0.80, 0.85) and (0.73, 0.77, 0.83) for WSL = 1, 2, 3, 4, 5, 6, 7, 8 and 9 PLs, respectively. Conclusions: Both the μ RSK and μ XU parametric images are feasible for evaluating human hepatic steatosis. The WSL exhibits little impact on the diagnosing performance of the μ RSK and μ XU parametric imaging. The μ XU parametric imaging provided improved performance compared to the μ RSK parametric imaging in characterizing human hepatic steatosis in vivo . %U https://qims.amegroups.org/article/view/29069 %V 9 %N 12 %P 1932-1947 %@ 2223-4306