TY - JOUR AU - Ma, Guangyu AU - Shao, Mingzhe AU - Xu, Baixuan AU - Tian, Jiahe AU - Chen, Yingmao PY - 2019 TI - Glomerular filtration rate measured by 99m Tc-DTPA Gates method is not significantly affected by the premature or delayed initiation of image acquisition JF - Quantitative Imaging in Medicine and Surgery; Vol 9, No 6 (June 30, 2019): Quantitative Imaging in Medicine and Surgery Y2 - 2019 KW - N2 - Background: This study was performed to examine the effect of non-synchronization of the radiotracer injection and image acquisition on estimates of the glomerular filtration rate (GFR) by the Gates’ method. Methods: A total of 218 volunteers were selected as the research subjects. Two-sample method (GFR dt ) and 99m Tc-DTPA dynamic renal imaging (GFR Gates ) were used for determination of the GFR. We took GFR dt as the reference method, and then took the peak time of blood perfusion phase as the new time origin to ensure that all patients were unified on the time-radioactivity count rate curve. We moved the radioactivity curve on 9 time points to simulate premature (+20/+15/+10/+5 seconds), synchronous (0 seconds), and delayed (−20/−15/−10/−5 seconds) image acquisition in relation to the completion of tracer injection; we then acquired 9 GFR Gates . The correlation and consistency of GFR Gates and GFR dt were analyzed. Variance analysis compared the differences between different GFR Gates . Results: All 9 GFR Gates had good correlation with GFR dt . GFR dt and GFR Gates derived from −5, −10 and −15 s had the best correlation (r=0.827, P<0.01). The consistency between GFR Gates derived from +20 s and GFR dt was the worst, and GFR Gates derived from –15 s and GFR dt was the best. There were no significant differences between the 9 GFR Gates . Conclusions: Non-synchronization of the radiotracer injection and image acquisition has no significant effect on the estimates of the GFR Gates if the premature or delayed time between image acquisition and tracer injection is not more than 20 seconds. UR - https://qims.amegroups.org/article/view/26722