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Atherosclerosis in intracranial or extracranial vessels in diabetic patients and the association with stroke subtype

  
@article{QIMS26050,
	author = {Li-Ming Wei and Yue-Qi Zhu and Yu-Qian Bao and Hai-Tao Lu and Pei-Lei Zhang and Yu-Wu Zhao and Mei Li and Jun-Gong Zhao},
	title = {Atherosclerosis in intracranial or extracranial vessels in diabetic patients and the association with stroke subtype},
	journal = {Quantitative Imaging in Medicine and Surgery},
	volume = {9},
	number = {6},
	year = {2019},
	keywords = {},
	abstract = {Background: Diabetes mellitus (DM) is associated with increased prevalence and severity of atherosclerosis. This study aimed to assess the prevalence and location of atherosclerosis in intracranial and extracranial vessels in diabetic patients and to investigate their association with ischemic stroke subtype. 
Methods: Diabetes patients (n=128) and nondiabetic patients (n=195) were enrolled. Brain MRI, MR angiography, and digital subtraction angiography (DSA) imaging findings in the two groups were retrospectively compared. The characteristics of atherosclerosis (prevalence, location, severity) and collateral flow in diabetic and nondiabetic patients and their association with stroke subtype were analyzed. 
Results: Atherosclerosis in extracranial vessels was more common in diabetes patients than in nondiabetic patients (43.8% vs. 23.1%; P65 years (OR, 2.55; 95% CI, 1.24–5.22; P=0.011) were independent risk factors for lacunar infarct. Diabetes patients with symptomatic extracranial stenosis or occlusion, combined with good collateral circulation, had significantly higher risk of lacunar infarction than nondiabetic patients (47.8% vs. 30.5%; P=0.045).
Conclusions: DM aggravates the severity of extracranial atherosclerosis. Lacunar stroke is relatively common in diabetic patients and could even be due to large artery disease (LAD).},
	url = {http://qims.amegroups.com/article/view/26050}
}