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Altered functional connectivity density in primary angle-closure glaucoma patients at resting-state

	author = {Linglong Chen and Shenghong Li and Fengqin Cai and Lin Wu and Honghan Gong and Chonggang Pei and Fuqing Zhou and Xianjun Zeng},
	title = {Altered functional connectivity density in primary angle-closure glaucoma patients at resting-state},
	journal = {Quantitative Imaging in Medicine and Surgery},
	volume = {9},
	number = {4},
	year = {2019},
	keywords = {},
	abstract = {Background: Primary angle-closure glaucoma (PACG) is a neurodegenerative disease. Previous structural and functional studies of functional magnetic resonance imaging (fMRI) have demonstrated widespread dysfunction of spontaneous activity in the PACG brain. In this study, we applied a data-driven graph theory approach of functional connectivity density (FCD) mapping to investigate the altered local and global functional connectivity (FC) of the cortex in PACG.
Methods: Forty-five PACG patients (53.28±10.79 years, 17 males/28 females) and 46 well-matched healthy controls (HCs) (52.67±11.01 years,18 males/28 females) received resting-state fMRI scans. All PACG patients finished complete ophthalmologic examinations, including retinal nerve fiber layer thickness (RNFLT), intraocular pressure (IOP), average cup to disc ratio (A-C/D), and vertical cup to disc ratio (V-C/D). We calculated the between-group FCD difference for short-range and long-range in each voxel. Then, we generated the intrinsic FC of the seed region with the whole brain. Finally, correlations were investigated between FCD value of the altered regions and clinical variables.
Results: PACG patients showed increased short-range FCD in the left inferior frontal gyrus (IFG)/insula/parahippocampal gyrus and right IFG/insula (P},
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