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Diffusion kurtosis imaging (DKI) of hepatocellular carcinoma: correlation with microvascular invasion and histologic grade

  
@article{QIMS24711,
	author = {Likun Cao and Jie Chen and Ting Duan and Min Wang and Hanyu Jiang and Yi Wei and Chunchao Xia and Xiaoyue Zhou and Xu Yan and Bin Song},
	title = {Diffusion kurtosis imaging (DKI) of hepatocellular carcinoma: correlation with microvascular invasion and histologic grade},
	journal = {Quantitative Imaging in Medicine and Surgery},
	volume = {9},
	number = {4},
	year = {2019},
	keywords = {},
	abstract = {Background: The aim of this study was to prospectively evaluate the diagnostic efficacy of diffusion kurtosis imaging (DKI) in predicting microvascular invasion (MVI) and histologic grade of hepatocellular carcinoma (HCC) with comparison to the conventional diffusion-weighted imaging (DWI).
Methods: This prospective study was approved by the Institutional Review Board, and written informed consent was obtained from all patients. From September 2015 to January 2017, 74 consecutive HCC patients were enrolled in this study. Preoperative magnetic resonance imaging including DKI protocol was performed, and patients were followed up for at least one year after surgery. Diffusion parameters including the mean corrected apparent diffusion coefficient (MD), mean apparent kurtosis coefficient (MK), and apparent diffusion coefficient (ADC) were calculated. Differences of diffusion parameters among different histopathological groups were compared. For parameters that were significantly different between pathological groups, receiver operating characteristics (ROC) curve analyses were performed to evaluate the diagnostic efficiency for identifying MVI and predicting high-grade HCC. Univariate and multivariate logistic regression analyses were used to evaluate the relative value of clinical and laboratory variables and diffusion parameters as risk factors for early recurrence (≤1 year).
Results: Among all the studied diffusion parameters, only MK differed significantly between the MVI-positive and MVI-negative group (0.91±0.10 vs. 0.82±0.09, P},
	url = {http://qims.amegroups.com/article/view/24711}
}