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Effect of segmentation from different diffusive metric maps on diffusion tensor imaging analysis of the cervical spinal cord

  
@article{QIMS24143,
	author = {Richu Jin and Yong Hu},
	title = {Effect of segmentation from different diffusive metric maps on diffusion tensor imaging analysis of the cervical spinal cord},
	journal = {Quantitative Imaging in Medicine and Surgery},
	volume = {9},
	number = {2},
	year = {2019},
	keywords = {},
	abstract = {Background: Segmentation is a crucial and necessary step in diffusion tensor imaging (DTI) analysis of the cervical spinal cord. In existing studies, different diffusive metric maps [B0, fractional anisotropy (FA) and axial diffusivity (AD) maps] have been involved in the segmentation of tissues of the cervical spinal cord. The selection of a diffusive metric map for segmentation may affect the accuracy of segmentation and then affect the validity and effectiveness of the extracted diffusive features. However, there are few discussions on this problem. Therefore, this study would like to examine the effect of segmentation based on different diffusive metric maps for DTI analysis of the cervical spinal cord. 
Methods: Twenty-nine healthy subjects and thirty patients with cervical spondylotic myelopathy (CSM) were finally included in this study. All subjects accepted DTI scanning at cervical levels from C2 to C7/T1. For healthy subjects, all cervical levels were included for analysis; while, for each patient, only one compressed cervical level was included. After DTI scanning, DTI metrics including B0, FA, AD, radial diffusivity (RD) and mean diffusivity (MD) were calculated. The evaluation was performed to B0, FA and AD maps from two aspects. First, the accuracy of segmentation was evaluated via a comparison between segmentation based on each diffusive metric map and segmentation based on an average image, which was acquired by averaging B0, FA, AD, RD and MD maps. The segmentation was achieved by a semi-automatic segmentation process, and the similarity between two segmentation results was denoted by the intersection of the union (IOU). Second, the diversity of extracted diffusive features was equalized as their performance in the classification of image pixels of different regions of interest (ROIs) and then was evaluated by mutual information (MI) and area under the curve (AUC). One-way ANOVA and Bonferroni’s post hoc tests were applied to compare the evaluation results. 
Results: One-way ANOVA suggested that there were differences (P},
	url = {http://qims.amegroups.com/article/view/24143}
}