TY - JOUR AU - Ma, Wanling AU - Zhang, Guangwen AU - Ren, Jing AU - Pan, Qi AU - Wen, Didi AU - Zhong, Jinman AU - Zhang, Zhuoli AU - Huan, Yi PY - 2018 TI - Quantitative parameters of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI): potential application in predicting pathological grades of pancreatic ductal adenocarcinoma JF - Quantitative Imaging in Medicine and Surgery; Vol 8, No 3 (April 30, 2018): Quantitative Imaging in Medicine and Surgery Y2 - 2018 KW - N2 - Background: The aim of this study was to compare intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) parameters such as standard apparent diffusion coefficient (ADC standard ), pure diffusion coefficient (D slow ), pseudodiffusion coefficient (Dfast) and perfusion fraction (ƒ) for differentiating pancreatic ductal adenocarcinoma (PDAC) with different pathological grades. Methods: Institutional Review Board of our hospital approved this study protocol. Subjects comprised 38 PDACs confirmed by pathology. Pancreatic multiple b values DWI with 15 b values of 0, 10, 20, 40, 60, 80, 100, 150, 200, 400, 800, 1,000, 1200, 1,500, and 2,000 s/mm 2 was performed using GE Discovery MR750 3.0T scanner. ADC standard , D slow , Dfast and ƒ values of all PDACs were calculated using mono- and bi-exponential models. Parameters of well/moderately differentiated and poorly differentiated PDAC were compared using Independent Sample t-test. P values Results: Mean D slow value of well/moderately differentiated PDAC was significantly lower than that of poorly differentiated PDAC (0.540×10 −3 vs . 0.676×10 −3 mm 2 /s, P vs . 38.4%, P slow (0.894>0.865). When the D slow value was less than or equal to 0.599×10 −3 mm 2 /s, the sensitivity and specificity were 100% and 84.6% respectively. When ƒ value was greater than 49.6%, the sensitivity and specificity were 92.0% and 84.6% respectively. Conclusions: D slow and ƒ derived from IVIM-DWI model can be used to distinguish well/moderately differentiated PDAC from poorly differentiated PDAC. And to serve this purpose, D slow and ƒ have high diagnostic performance. IVIM-DWI is a promising and non-invasive tool for predicting pathological grade of PDAC. UR - https://qims.amegroups.org/article/view/19221