TY - JOUR AU - Xie, Chao-Lian AU - Zhang, Mao AU - Chen, Yong AU - Hu, Ran AU - Tang, Meng-Yue AU - Chen, Tian-Wu AU - Xue, Hua-Dan AU - Jin, Zheng-Yu AU - Zhang, Xiao-Ming PY - 2018 TI - Spleen and splenic vascular involvement in acute pancreatitis: an MRI study JF - Quantitative Imaging in Medicine and Surgery; Vol 8, No 3 (April 30, 2018): Quantitative Imaging in Medicine and Surgery Y2 - 2018 KW - N2 - Background: To investigate the spleen and splenic vascular involvement in acute pancreatitis (AP) and their correlations with the severity of AP using magnetic resonance imaging (MRI). Methods: MRI of 239 patients with AP was retrospectively reviewed to assess splenic and splenic vascular complications, and the severity of AP. The severity of AP was graded by the MRI severity index (MRSI) and the New Revised Classification of AP 2012. The intravoxel incoherent motion (IVIM) parameters (D, D*, and f) of spleen were measured. Thirty-five subjects without pancreatic and splenic disorders were enrolled as controls for IVIM parameters. Results: Among the 239 patients with AP, splenomegaly (16.7%), splenic infarction (0.4%), splenic vein thrombosis (4.2%), phlebitis (7.5%) and arteritis (4.2%) were observed. Splenic vascular involvement was positively correlated with the severity of AP based on both the MRSI and the New Revised Classification of AP 2012 (P vs . (0.210±0.095) (P=0.023). In AP patients with and without splenomegaly, f = (0.240±0.091) vs . (0.203±0.095) (P=0.000). Conclusions: Splenic vascular involvement and splenomegaly are common in AP, the vascular involvement was associated with the severity of AP, this complication should be considered when severity and prognosis of AP were assessed. Quantitative analysis of the spleen with IVIM might be a useful imaging biomarker for splenic perfusion changes in AP, especially in those with splenomegaly. UR - https://qims.amegroups.org/article/view/18970