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Principal component analysis-T voxel based relaxometry of the articular cartilage: a comparison of biochemical patterns in osteoarthritis and anterior cruciate ligament subjects

  
@article{QIMS12875,
	author = {Valentina Pedoia and Colin Russell and Allison Randolph and Xiaojuan Li and Sharmila Majumdar and AF-ACL Consortium},
	title = {Principal component analysis-T 1ρ  voxel based relaxometry of the articular cartilage: a comparison of biochemical patterns in osteoarthritis and anterior cruciate ligament subjects},
	journal = {Quantitative Imaging in Medicine and Surgery},
	volume = {6},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Background: Quantitative MR, including T1ρ mapping, has been extensively used to probe early biochemical changes in knee articular cartilage of subjects with osteoarthritis (OA) and others at risk for cartilage degeneration, such as those with anterior cruciate ligament (ACL) injury and reconstruction. However, limited studies have been performed aimed to assess the spatial location and patterns of T1ρ. In this study we used a novel voxel-based relaxometry (VBR) technique coupled with principal component analysis (PCA) to extract relevant features so as to describe regional patterns and to investigate their similarities and differences in T1ρ maps in subjects with OA and subjects six months after ACL reconstruction (ACLR). 
Methods: T1ρ quantitative MRI images were collected for 180 subjects from two separate cohorts. The OA cohort included 93 osteoarthritic patients and 25 age-matched controls. The ACLR-6M cohort included 52 patients with unilateral ACL tears who were imaged 6 months after ACL reconstruction, and 10 age-matched controls. Non-rigid registration on a single template and local Z-score conversion were adopted for T1ρ spatial and intensity normalization of all the images in the dataset. PCA was used as a data dimensionality reduction to obtain a description of all subjects in a 10-dimensional feature space. Logistic linear regression was used to identify distinctive features of OA and ACL subjects 
Results: Global prolongation of the Z-score was observed in both OA and ACL subjects compared to controls [higher values in 1st principal component (PC1); P=0.01]. In addition, relaxation time differences between superficial and deep cartilage layers of the lateral tibia and trochlea were observed to be significant distinctive features between OA and ACL subjects. OA subjects demonstrated similar values between the two cartilage layers [higher value in 2nd principal component (PC2); P=0.008], while ACL reconstructed subjects showed T1ρ prolongation specifically in the cartilage superficial layer (lower values in PC2; P},
	url = {http://qims.amegroups.com/article/view/12875}
}