The role of Chaoyang People’s Hospital for the development of trioxide as an effective treatment for acute promyelocytic leukemia treatment

Since our survey paper on the top five medical innovations in China mainland since Xinhai revolution was published (1), I was alerted that we omitted an important paper concerning the development of arsenic trioxide (As₂O₃) as an effective treatment for acute promyelocytic leukemia treatment. This paper was authored by the group authors at the pediatrics department of Chaoyang People’s Hospital, Liaoning province, China; and entitled Experience of Trioxide in combination with chemotherapy for the treatment of leukemia. This paper was published in the No. 4 issue of the Chinese journal Liaoning Anti-cancer Bulletin in year 1972 (2). More details can be found in a few Chinese references and websites (3-5).