Radiological changes of spine and liver in a case of Alagille syndrome

Alagille syndrome is a well-known, clinically important, but infrequent disease. It is an autosomal dominant disorder characterized by genetic abnormalities of Jag 1 and the Notch signaling pathway (1,2). Alagille syndrome is histologically characterized by a paucity of intrahepatic bile ducts leading to chronic cholestasis.